background and objectives: involvement of lymph nodes is an important prognostic factor in the most cancers, including colorectal cancer. in the recent years, invasion to blood and lymphatic vessels has been shown to predict involvement of lymph nodes and the number of involved nodes has been less studied issue. the aim of this study was determination of the relationship between the size of col...

radiation therapy is considered as one of the main methods in cancer treatment. in this method, determination of exact location and geometric properties of tumor is necessary for treatment planning that leads to increased accuracy and output of treatment and reduction of healthy tissue dose. for this purpose, the aim of the present study has been physiological transmission of gallium as a pharm...

Background: In addition to determining the exact tumor location and its geometric features, an increase of the effective tumor atomic number will enhances the chance in treating the tumoral cells under suitable radiation. In the present study, we assessed metrezoate-labeled gallium transmission in Burkett lymphatic cells. Materials and Methods: Human Burkitt lymphatic cells were grown ...

background: in addition to determining the exact tumor location and its geometric features, an increase of the effective tumor atomic number will enhances the chance in treating the tumoral cells under suitable radiation. in the present study, we assessed metrezoate-labeled gallium transmission in burkett lymphatic cells. materials and methods: human burkitt lymphatic cells were grown in cultur...

We studied the associations of lymphatic invasion and lymphatic vessel density around tumors with lymph node (LN) status in renal cell carcinoma (RCC) by immunohistochemical analysis using D2-40 antibody as a lymphatic marker. Surgically removed specimens from 76 cases with RCC, including 16 cases with LN metastasis, were used. Lymphatic vessel density around the tumor increased compared with n...

Lymphangiogenic growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D have been shown to promote lymphatic metastasis by inducing tumor-associated lymphangiogenesis. In this study, we have investigated how tumor cells gain access into lymphatic vessels and at what stage tumor cells initiate metastasis. We show that VEGF-C produced by tumor cells induced extensive lymphatic sprou...

Endothelial progenitor cells have been shown to contribute to angiogenesis in various tumor models. Here, we have studied the relative contributions of bone marrow (BM)-derived endothelial progenitors and pre-existing lymphatic vessels to tumor lymphangiogenesis. We did not find significant incorporation of genetically marked BM-derived cells in lymphatic vessels during tumor- or vascular endot...

Metastasis is the most lethal step of cancer progression in patients with invasive melanoma. In most human cancers, including melanoma, tumor dissemination through the lymphatic vasculature provides a major route for tumor metastasis. Unfortunately, molecular mechanisms that facilitate interactions between melanoma cells and lymphatic vessels are unknown. Here, we developed an unbiased approach...

Because of the deficiency lymphatic reflux in tumor, retention tumor interstitial fluid causes aggravation pressure (TIP), which leads to unsatisfactory penetration nanomedicine. It is main inducement recurrence and metastasis. Herein, we design a pyroelectric catalysis-based Nano-lymphatic decrease TIP for enhanced treatments. realizes photothermal therapy decomposition under NIR-II laser irra...

The metastatic spread of tumor cells is the most lethal aspect of cancer and often occurs via the lymphatic vasculature. Both experimental tumor models and human clinicopathologic data indicate that growth of lymphatic vessels (lymphangiogenesis) near solid tumors is often associated with lymph node metastasis. Changes in the adhesive properties of lymphatic endothelium near tumors may also fac...